Selected Publications

Books

Protein Metabolism and Homeostasis in Aging (2010) Edited by Nektarios Tavernarakis. Springer-Verlag New York Inc., Series: Advances in Experimental Medicine and Biology, New York, NY, USA.

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Journal articles

Charmpilas N., Sotiriou A., Axarlis K., Tavernarakis N. and Hoppe T. (2024) Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans. Cell Reports, 43: 114336.
(Supplementary material)
See also: Commentary in Trends in Cell Biology
Hofer S. J., Daskalaki I., Bergmann M., Friscic J., Zimmermann A., Mueller M. I., Abdellatif M., Nicastro R., Masser S., Durand S., Nartey A., Waltenstorfer M., Enzenhofer S., Faimann I., Gschiel V., Bajaj T., Niemeyer C., Gkikas I., Pein L., Cerrato G., Pan H., Liang Y. T., Tadic J., Jerkovic A., Aprahamian F., Robbins C. E., Nirmalathasan N., Habisch H., Annerer E., Dethloff F., Stumpe M., Grundler F., Wilhelmi de Toledo F., Heinz D. E., Koppold D. A., Rajput Khokhar A., Michalsen A., Tripolt N. J., Sourij H., Pieber T., de Cabo R., McCormick M., Magnes C., Kepp O., Dengjel J., Sigrist S. J., Gassen N. C., Sedej S., Madl T., De Virgilio C., Stelzl U., Hoffmann M. H., Eisenberg T., Tavernarakis N., Kroemer G. and Madeo F. (2024) Spermidine is essential for fasting-mediated autophagy and longevity. Nature Cell Biology, DOI: 10.1038/s41556-024-01468-x.
(Supplementary files: 1 | 2)
Daskalaki I., Markaki M., Gkikas I. and Tavernarakis N. (2023) Local coordination of mRNA storage and degradation in the vicinity of mitochondria modulates Caenorhabditis elegans somatic ageing. EMBO Journal, e112446.
(Supplementary material)
Petratou D., Gjikolaj M., Kaulich E., Schafer W. and Tavernarakis N. (2023) A proton-inhibited DEG/ENaC ion channel maintains neuronal ionstasis and promotes neuronal survival under stress. iScience, 26: 107117.
(Supplementary file)
Tavernarakis N. (2023) Remote control of autophagy and metabolism in the liver. Cell Metabolism, 35: 725-727.
Ploumi C., Kyriakakis E. and Tavernarakis N. (2023) Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans. Cell Death and Disease, 14: 110.
(Supplementary file)
Palikaras K., Mari M., Ploumi C., Princz A., Filippidis G. and Tavernarakis N. (2023) Age-dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans. Aging Cell, 22: e13788.
(Supplementary files: 1 | 2)
Papandreou M.-E., Konstantinidis G. and Tavernarakis N. (2023) Nucleophagy delays ageing and preserves germline immortality. Nature Aging, 3: 34-46.
Tavernarakis N. (2023) Research Briefing: Nuclear autophagy promotes longevity and germline immortality. Nature Aging, 3: 11-12.
Lionaki E., Gkikas I., Daskalaki I., Ioannidi M.-K., Klapa M. I. and Tavernarakis N. (2022) Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Nature Communications, 13: 651.
(Supplementary files: 1 | 2 | 3)
See also: Commentary in Trends in Endocrinology & Metabolism
Zaninello M., Palikaras K., Tavernarakis N. and Scorrano L. (2022) Sustained intracellular calcium mediates neuronal mitophagy in models of autosomal dominant optic atrophy. Cell Death and Differentiation, 29: 167-177.
(Supplementary material)
SenGupta T., Palikaras K., Esbensen Y. Q., Konstantinidis G., Naranjo Galindo F. J., Achanta K., Kassahun H., Stavgiannoudaki I., Bohr V. A., Akbari M., Gaare J., Tzoulis C., Tavernarakis N. and Nilsen H. (2021) Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson's disease pathology. Cell Reports, 36: 109668.
(Supplementary material)
Princz A., Pelisch F. and Tavernarakis N. (2020) SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans. Scientific Reports, 10: 15513.
(Supplementary material)
See also: Commentary in Rejuvenation Research | F1000 Biology evaluation
Tavernarakis N. (2020) Inflammation brakes mitochondrial metabolism in obesity. Nature Immunology, 21: 1143-1145.
Zaninello M., Palikaras K., Naon D., Iwata K., Herkenne S., Quintana-Cabrera R., Semenzato M., Grespi F., Ross-Cisneros F. N., Carelli V., Sadun A. A., Tavernarakis N. and Scorrano L. (2020) Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy. Nature Communications, 11, 4029.
(Supplementary files: 1 | 2 | 3 | 4 | 5)
Markaki M. and Tavernarakis N. (2020) Caenorhabditis elegans as a model system for human diseases. Current Opinion in Biotechnology, 63: 118-125.
Tavernarakis N. (2019) Ageing: Neural excitation moderates lifespan (Moderation of neural excitation promotes longevity). Nature, 574: 338-340.
Charmpilas N. and Tavernarakis N. (2020) Mitochondrial maturation drives germline stem cell differentiation in Caenorhabditis elegans. Cell Death and Differentiation, 27: 601-617.
(Supplementary material)
Bravo-San Pedro J. M., Sica V., Martins I., Pol J., Loos F., Maiuri M. C., Durand S., Bossut N., Aprahamian F., Anagnostopoulos G., Niso-Santano M., Aranda F., Ramirez-Pardo I., Lallement J., Denom J., Boedec E., Gorwood P., Ramoz N., Clement K., Pelloux V., Rohia A., Pattou F., Raverdy V., Caiazzo R., Denis R. G. P., Boya P., Galluzzi L., Madeo F., Migrenne-Li S., Cruciani-Guglielmacci C., Tavernarakis N., Lopez-Otin C., Magnan C. and Kroemer G. (2019) Acyl-CoA-Binding Protein is a lipogenic factor that triggers food intake and obesity. Cell Metabolism, 30: 754-767.
Lou G., Palikaras K., Lautrup S., Scheibye-Knudsen M., Tavernarakis N. and Fang E. F. (2019) Mitophagy and neuroprotection. Trends in Molecular Medicine, 26: 8-20.
Fang E. F., Hou Y., Palikaras K., Adriaanse B. A., Kerr J. S., Yang B., Lautrup S., Hasan-Olive M., Caponio D., Dan X., Rocktaschel P., Croteau D. L., Akbari M., Greig N. H., Fladby T., Nilsen H., Cader M. Z., Mattson M. P., Tavernarakis N. and Bohr V. A. (2019) Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nature Neuroscience, 22: 401-412.
(Supplementary material, Table S1)
Papandreou M.-E. and Tavernarakis N. (2019) Nucleophagy: from homeostasis to disease. Cell Death and Differentiation, 26: 630-639.
Rieckher M., Markaki M., Princz A., Schumacher B. and Tavernarakis N. (2018) Maintenance of proteostasis by P body-mediated regulation of eIF4E availability during ageing in Caenorhabditis elegans. Cell Reports, 25: 199-211.
(Supplementary material)
Palikaras K., Lionaki E. and Tavernarakis N. (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nature Cell Biology, 20: 1013-1022.
Nikoletopoulou V. and Tavernarakis N. (2018) Regulation and roles of autophagy at synapses. Trends in Cell Biology, 28: 646-661.
Pietrocola F., Castoldi F., Markaki M., Lachkar S., Chen G., Enot D. P., Durand S., Bossut N., Tong M., Malik S. A., Loos F., Dupont N., Marino G., Abdelkader N., Madeo F., Maiuri M. C., Kroemer R., Codogno P., SadoshimaJ., Tavernarakis N. and Kroemer G. (2018) Aspirin recapitulates features of caloric restriction. Cell Reports, 22: 2395-2407.
(Supplementary material, Table S1, Table S2)
Nikoletopoulou V., Sidiropoulou K., Kallergi E., Dalezios Y. and Tavernarakis N. (2017) Modulation of autophagy by BDNF underlies synaptic plasticity. Cell Metabolism, 26: 230-242.
(Supplementary material)
Kyriakakis E., Charmpilas N. and Tavernarakis N. (2017) Differential adiponectin signalling couples ER stress with lipid metabolism to modulate ageing in C. elegans. Scientific Reports, 7: 5115.
(Supplementary material)
Schiavi A., Maglioni S., Palikaras K., Shaik A., Strapazzon F., Brinkmann V., Torgovnick A., Castelein N., De Henau S., Braeckman B. P., Cecconi F., Tavernarakis N. and Ventura N. (2015) Iron starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Current Biology, 25: 1810-1822.
(Supplementary files: 1 | 2)
Palikaras K., Lionaki E. and Tavernarakis N. (2015) Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis. Cell Death and Differentiation, 22: 1399-1401.
Palikaras K., Lionaki E. and Tavernarakis N. (2015) Coordination of mitophagy and mitochondrial biogenesis during ageing in Caenorhabditis elegans. Nature, 521: 525-528.
(Supplementary material)
See also: F1000 Biology evaluation
Niso-Santano M., Malik S. A., Pietrocola F., Bravo-San Pedro J. M., Marino G., Cianfanelli V., Ben-Younes A., Troncoso R., Markaki M., Sica V., Izzo V., Chaba K., Bauvy C., Dupont N., Kepp O., Rockenfeller P., Wolinski H., Madeo F., Lavandero S., Codogno P., Harper F., Pierron G., Tavernarakis N., Cecconi F., Maiuri M. C., Galluzzi L. and Kroemer G. (2015) Unsaturated fatty acids induce non-canonical autophagy. EMBO Journal, 34: 1025-1041.
(Supplementary material)
See also: Commentary in EMBO Journal

Nikoletopoulou V., Papandreou M.-E. and Tavernarakis N. (2014) Autophagy in the physiology and pathology of the central nervous system. Cell Death and Differentiation, 22: 398-407.

Nikoletopoulou V., Kyriakakis E. and Tavernarakis N. (2014) Cellular and molecular longevity pathways: The old and the new. Trends in Endocrinology and Metabolism, 25: 212-223.

Buttner S., Habernig L., Broeskamp F., Ruli D, Vogtle F. N., Vlachos M., Macchi F., Kuttner V., Carmona-Gutierrez D., Eisenberg T., Ring J., Markaki M., Taskin A. A., Benke S., Ruckenstuhl C., Braun R., Van den Haute C., Bammens T., van der Perren A., Frohlich K.-U., Winderickx J., Kroemer G., Baekelandt V., Tavernarakis N., Kovacs G. G., Dengjel J., Mesinger C., Sigrist S. J. and Madeo F. (2013) Endonuclease G mediates a-synuclein cytotoxicity during Parkinson's disease. EMBO Journal, 32: 3041-3054.

Coburn C., Allman E., Mahanti P., Benedetto A., Cabreiro F., Pincus Z., Matthijssens F., Araiz C., Mandel A., Vlachos M., Edwards S.-A., Fischer G., Davidson A., Pryor R., Stevens A., Slack F., Tavernarakis N., Braeckman B. P., Schroeder F., Nehrke K. and Gems D. (2013) Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biology, 11: e1001613.
(Supplementary material)
See also: F1000 Biology evaluations

Buttner S., Faes L., Reichelt W., Broeskamp F., Habernig L., Benke S., Kourtis N., Ruli D., Carmona-Gutierrez D., Eisenberg T., D'hooge P., Ghillebert R., Franssens V., Harger A., Pieber T. R., Freudenberger P., Kroemer G., Sigrist S. J., Winderickx J., Callewaert G., Tavernarakis N. and Madeo M. (2013) The Ca(2+)/Mn(2+) ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models. Cell Death and Differentiation, 20: 465-477.

Kourtis N., Nikoletopoulou V. and Tavernarakis N. (2012) Small heat shock proteins protect from heat stroke-associated neurodegeneration. Nature, 490: 213-218.
(Supplementary material)
See also: Commentary in Nature Reviews Molecular Cell Biology | F1000 Biology evaluations

Troulinaki K. and Tavernarakis N. (2012) Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO Journal, 31: 654-666.
(Supplementary files: 1 | 2)

Morselli E., Marino G., Bennetzen M., Eisenberg T., Megalou E., Schroeder S., Cabrera S., Benit P., Rustin P., Criollo A., Shen S., Kepp O., Maiuri C., Horio Y., Lopez-Otin C., Andersen J. S., Tavernarakis N., Madeo F., and Kroemer G. (2011) Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. Journal of Cell Biology, 192: 615-629.
(Supplementary files: 1 | 2 | 3)

Kourtis N. and Tavernarakis N. (2011) Cellular stress response pathways and ageing: intricate molecular relationships. EMBO Journal, 30: 2520-2531.

Madeo F., Tavernarakis N. and Kroemer G. (2010) Can autophagy promote longevity? Nature Cell Biology, 12: 842-846.

Artal-Sanz M. and Tavernarakis N. (2009) Prohibitin couples diapause signaling to mitochondrial energy metabolism during ageing in Caenorhabditis elegans. Nature, 461: 793-797.
(Supplementary material)
See also: Nature Editor's summary

Eisenberg T., Knauer H., Schauer A., Fussi H., Buttner S., Ruckenstuhl C., Carmona-Gutierrez D., Ring J., Schroder S., Antonacci L., Fahrenkrog B., Deszcz L., Hartl R., Magnes C., Sinner F., Schraml E., Criollo A., Megalou E., Weiskopf D., Laun P., Heeren G., Breitenbach M., Grubeck-Loebenstein B., Herker E., Frohlich K.-U., Tavernarakis N., Minois N., Kroemer G. and Madeo F. (2009) Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11: 1305-1314.
(Suppmementary information)
See also: Nature Cell Biology News and Views | F1000 Biology evaluation

Artal-Sanz M. and Tavernarakis N. (2009) Prohibitin and mitochondrial biology. Trends in Endocrinology and Metabolism, 20: 394-401.

Kourtis N. and Tavernarakis N. (2009) Autophagy and cell death in model organisms. Cell Death and Differentiation, 16: 21-30.

Voglis G. and Tavernarakis N. (2008) A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling. EMBO Journal, 27: 3288-3299.
(Supplementary Material)

Galluzzi L., Joza N., Tasdemir E., Maiuri M. C., Hengartner M., Abrams J. M., Tavernarakis N., Penninger J., Madeo F. and Kroemer G. (2008) No death without life: vital functions of apoptotic effectors. Cell Death and Differentiation,15: 1113-1123.

Tasdemir E., Maiuri M. C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmanrk U., Samara C., Pinton P., Vicencio J.-M., Carnuccio R., Moll U. M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F. and Kroemer G. (2008) Regulation of autophagy by cytoplasmic p53. Nature Cell Biology, 10: 676-687.
(Supplementary material)
See also: Nature Cell Biology News and Views | F1000 Biology evaluation

Tavernarakis N. (2008) Ageing and the regulation of protein synthesis: A balancing act? Trends in Cell Biology, 18: 228-235.

Samara C., Syntichaki P. and Tavernarakis N. (2008) Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death and Differentiation, 15: 105-112.
(Supplementary material)

Syntichaki P. Troulinaki K. and Tavernarakis N. (2007) eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature, 445: 922-926.
(Supplementary material)
See also: Nature Editor's summary | Commentary in the Journal of Cell Biology

Maiuri M. C., Le Toumelin G., Criollo A., Rain J.-C., Gautier F., Juin P., Tasdemir E., Pierron G., Troulinaki K., Tavernarakis N., Hickman J. A., Geneste O. and Kroemer G. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO Journal, 26: 2527-2539.
(Supplementary Figures: 1 | 2 | 3 | 4)
See also: F1000 Biology evaluation

Liolios K., Tavernarakis N., Hugenholtz P. and Kyrpides N. C. (2006) The Genomes On Line Database (GOLD) v.2: a monitor of Genome Projects world-wide. Nucleic Acids Research, 34: D332-D334.

Artal-Sanz M., Samara C., Syntichaki P. and Tavernarakis N. (2006) Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. The Journal of Cell Biology, 173: 231-239.
See also: Commentary in the Journal of Cell Biology

Voglis G. and Tavernarakis N. (2006) The role of synaptic ion channels in synaptic plasticity. EMBO Reports, 7: 1104-1110.

Syntichaki P., Samara C. and Tavernarakis N. (2005) The Vacuolar H+-ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Current Biology, 15: 1249-1254.
(Supplementary material)

Syntichaki P. and Tavernarakis N. (2004) Genetic models of mechanotransduction: The nematode Caenorhabditis elegans. Physiological Reviews, 84: 1097-1153.

Syntichaki P. and Tavernarakis N. (2003) The biochemistry of neuronal necrosis: Rogue biology? Nature Reviews Neuroscience, 4: 672-684.

Syntichaki P., Xu K., Driscoll M. and Tavernarakis N. (2002) Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature, 419: 939-944.
(Supplementary material)
See also: Science STKE Editors choice | F1000 Biology evaluation

Syntichaki P. and Tavernarakis N. (2002) Death by necrosis: Uncontrollable catastrophe or is there order behind the chaos? EMBO Reports, 3: 604-609.
(Supplementary material)

Boutla A, Kalantidis K, Tavernarakis N, Tsagris M and Tabler M. (2002) Induction of RNA interference in Caenorhabditis elegans by RNAs derived from plants exhibiting post-transcriptional gene silencing. Nucleic Acids Research 30: 1688-1694.

Xu K., Tavernarakis N. and Driscoll M. (2001) Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca2+ release from the endoplasmic reticulum. Neuron, 31: 957-971.
See also: Science STKE Editors choice

Tavernarakis N., Everett J., Kyrpides N. and Driscoll M. (2001) Structural and functional features of the intracellular amino-termini of DEG/ENaC ion channels. Current Biology, 11: R205-R208.
(Supplementary material)

Driscoll M. and Tavernarakis N. (2000) Closing in on a mammalian touch receptor. Nature Neuroscience, 3: 7-9.

Tavernarakis N., Wang S. L., Dorovkov M., Ryazanof A. and Driscoll M. (2000) Heritable and inducible interference by dsRNA. Nature Genetics, 24: 180-183.

Winnier A. R., Meir J. Y.-J., Ross J. M., Tavernarakis N., Driscoll M., Ishihara T., Katsoura I. and Miller D. M. III. (1999) Unc-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Genes and Development, 13: 2774-2786.

Tavernarakis, N., Driscoll, M. and Kyrpides, N.C. (1999) The SPFH domain: a universal motif in stomatins and membrane-associated proteins implicated in regulating targeted protein turnover. Trends in Biochemical Sciences, 24: 425-427.

Harbinder S., Tavernarakis N., Herndon L. A., Kinnell M., Xu S. Q., Fire A. and Driscoll M. (1997) Genetically targeted cell disruption in Caenorhabditis elegans. Proceedings of the National Academy of Sciences USA, 94: 13128-13133.

Tavernarakis N. and Driscoll M. (1997) Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans. Annual Reviews of Physiology, 59: 659-689.

Tavernarakis N., Shreffler W., Wang S. L. and Driscoll M. (1997) unc-8, a member of the DEG/ENaC superfamily, encodes a subunit of a candidate stretch-gated motor neuron channel that modulates locomotion in C. elegans. Neuron, 18: 107-119.

Kyrpides N., Tavernarakis N., Papamatheakis J. and Thireos G.(1995) A transient GCN4 mRNA destabilization follows GCN4 translational derepression. Journal of Biological Chemistry, 270: 17317-17320.
Equal contribution by Kyrpides N. and Tavernarakis N.

Tavernarakis N. and Thireos G. (1995) A recombinatorial method useful for cloning dominant alleles in Saccharomyces cerevisiae. Nucleic Acids Research, 23: 537-538.